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Protocol: vaccination of paediatric patients with a known PEG-asparaginase allergy.

Journal: EJC Paediatric Oncology

Article Title: Safety of mRNA-based COVID-19 vaccination in paediatric patients with a PEG-asparaginase allergy

doi: 10.1016/j.ejcped.2022.100002

Figure Lengend Snippet: Protocol: vaccination of paediatric patients with a known PEG-asparaginase allergy.

Article Snippet: In patients with a negative SPT and a severe allergic reaction to PEG-asparaginase in the past, the mRNA vaccine (Pfizer-BioNTech) was administered in a tapered dosing schedule starting with 0.05 ml intramuscularly, if tolerated after thirty minute observation time followed 0.25 ml intramuscularly.

Techniques:

Patient characteristics All 12 patients had a medical history of acute lymphoblastic leukemia (ALL). Patient 3 had a stem cell transplantation. All patients had subsequent macrogol (PEG 3350) exposure. All patients were vaccinated with the mRNA-based COVID-19 vaccine of Pfizer/BioNTech.

Journal: EJC Paediatric Oncology

Article Title: Safety of mRNA-based COVID-19 vaccination in paediatric patients with a PEG-asparaginase allergy

doi: 10.1016/j.ejcped.2022.100002

Figure Lengend Snippet: Patient characteristics All 12 patients had a medical history of acute lymphoblastic leukemia (ALL). Patient 3 had a stem cell transplantation. All patients had subsequent macrogol (PEG 3350) exposure. All patients were vaccinated with the mRNA-based COVID-19 vaccine of Pfizer/BioNTech.

Article Snippet: In patients with a negative SPT and a severe allergic reaction to PEG-asparaginase in the past, the mRNA vaccine (Pfizer-BioNTech) was administered in a tapered dosing schedule starting with 0.05 ml intramuscularly, if tolerated after thirty minute observation time followed 0.25 ml intramuscularly.

Techniques: Transplantation Assay

Regulatory‐approved PEGylated biopharmaceuticals.

Journal: Angewandte Chemie (International Ed. in English)

Article Title: Chemical Approaches to Synthetic Drug Delivery Systems for Systemic Applications

doi: 10.1002/anie.202203942

Figure Lengend Snippet: Regulatory‐approved PEGylated biopharmaceuticals.

Article Snippet: Oncaspar® , PEG‐asparaginase, Pegaspargase , 5 kDa [69–82] , Linear/mPEG‐SS , 1994 , Enzon.

Techniques: